A hand specialist may consider treatment with XIAFLEX® if you have a cord that can be felt, along with: Contractures ranging from less severe to more severe. Dupuytren's Contracture - Treatment Comparison Chart. For more information, ask your healthcare provider or pharmacist. Ask a hand specialist if XIAFLEX® is right for you. The cord was injected with XIAFLEX® at each location and a finger extension procedure was performed for each joint 48 hours later, MP=metacarpophalangeal PIP=proximal interphalangeal Individual results may vary. The complication of Dupuytren's treatment most feared by surgeons is usually a nerve … XIAFLEX, supplied as a lyophilized powder, must be reconstituted with the provided diluent prior to use [see Dosage and Administration (2.1)] . You may wish to follow the progression with a tabletop test, which you can do on your own.Treatment involves removing or breaking apart the cords that are pulling your fingers toward your palm. A Dupuytren's contraction is caused by an abnormal accumulation of collagen (scar) in the tissue beneath the skin of the palm of the hand. The following are examples of finger exercises you can do at home. Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). Visalia California Orthopedic Surgeon Doctors physician directory - Read about Dupuytren's contracture treatment options: Xiaflex injection, needle aponeurotomy, ultrasound, and cortisone injection. Your first follow-up visit with the doctor will be approximately 1 to 3 days after the injection. Afterward, they report side effects and complications that were far worse than they were prepared for. If you have any questions, talk to your doctor. Studies show that prescription XIAFLEX®, along with a finger extension procedure, may help straighten or nearly straighten the affected finger and improve range of motion after up to 3 injections. Please see the full Prescribing Information, including Medication Guide. Dupuytren disease is a systemic disorder which most visibly affects the hands. Treatment with XIAFLEX® is performed in a doctor’s office. In cases of Peyronie’s disease, the curvature of the penis must be more than 30 degrees. Learn about causes, risk factors, and symptoms. XIAFLEX approved in Japan for treatment of patients with Dupuytren's contracture. It is not known if XIAFLEX ® is safe and effective in children under the age of 18. This patient had a cord that could be felt causing a contracture of the MP joint of the left ring finger. Please see the full Prescribing Information, including Medication Guide. https://www.webmd.com/drugs/2/drug-153667/xiaflex-injection/details TREATMENT COMPARISON CHART. It is used for treating Dupuytren's contracture. Lay your hand flat on the table. No personal information (including email addresses) about you or the recipient will be collected from this email notification features offered by Endo Pharmaceuticals. This information should not take the place of talking with your doctor or healthcare professional. Learn about causes, risk factors, and symptoms. These are not all of the possible side effects with XIAFLEX®. Click CONTINUE if you are a healthcare professional. The traditional "treatment" recommendation for people with this condition was to wait … If you still have the cord, the doctor may try to extend the treated finger(s) and “break” the cord. The doctor may use local anesthetic during this procedure. A hand specialist may consider XIAFLEX® if you have Dupuytren's contracture with a cord that can be felt. Please see the full Prescribing Information, including Medication Guide. The patient leaflet for Xiaflex lists considerations when caution must be taken for using this treatment: known allergy to the ingredients. If you are told to stop taking a blood thinner before your XIAFLEX® injection, your healthcare provider should tell you when to restart the blood thinner. Xiaflex is used to treat Dupuytren's contracture in adults. This can be done in several ways. Instead, you can wait and see if Dupuytren's contracture progresses. XIAFLEX® is a registered trademark of Endo International plc or one of its affiliates. Upland California Orthopedic Surgeon Doctors physician directory - Dupuytren's contracture treatment options include Xiaflex injection, needle aponeurotomy, ultrasound, and cortisone injection. There is a risk of anaphylactic … Repeat the exercise 4 times a day. The Dupuytren Contracture Institute is not against Xiaflex injections or surgery for Dupuytren’s contracture. Xiaflex, a treatment by injecting collagenase enzymes in the palm of the affected hand is now available in Canada. Lay your hand flat on the table. XIAFLEX ® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. Arch your knuckles back 10 times in a row. Observation. Next day cord break left open wound which could not be stitched and took several weeks to heal. User Reviews for Xiaflex to treat Dupuytren's contracture Xiaflex has an average rating of 2.0 out of 10 from a total of 12 ratings for the treatment of Dupuytren's contracture. The results of this medical treatment without surgery are surprising. For Dupuytren's contracture: “I was very disappointed with Xiaflex. XIAFLEX® is a registered trademark of Endo International plc or one of its affiliates. Repeat the exercise 4 times a day. Ask your healthcare provider or pharmacist for a list of these medicines if you are unsure. Do not receive XIAFLEX® if you have had an allergic reaction to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX®, or to any other collagenase product. I had procedure involving 3 shots to correct Dupuytrens contracture in right hand, small finger. Use these questions to help guide your discussion with a hand specialist. It is not known if XIAFLEX ® is safe and effective in children under the age of 18. You are now leaving the XIAFLEX® website. … Learn about causes, risk factors, and symptoms. Considering treatment with XIAFLEX®? XIAFLEX® is an FDA-approved, nonsurgical treatment for adults with Dupuytren’s contracture when a “cord” can be felt. MP=metacarpophalangeal Individual results may vary, This patient had a cord that could be felt causing a contracture of the PIP joint of the left pinky finger. Raise each finger up one at a time and hold for 5 seconds. XIAFLEX® should be injected by a healthcare provider who is experienced in injection procedures of the hand and treating people with Dupuytren's contracture. Xiaflex is a prescription medication used to treat adults with Dupuytren’s contracture once a cord can be felt in the palm. Shots were very painful and syringe supplied by Endo "blew apart" on 2 nd shot. XIAFLEX should be administered by a healthcare provider experienced in injection procedures of the hand and in the treatment of patients with Dupuytren’s contracture. Xiaflex treatment of a Dupuytren cord requires a doctor to make multiple injections of Xiaflex into the palm of the hand into the Dupuytren’s cord at various points. Injection of XIAFLEX ® into collagen-containing structures such as tendons or ligaments of the hand may result in damage to those structures and possible permanent injury such as tendon rupture or ligament damage. If you have more than 1 contracture, your doctor may give you 2 injections in 1 of your hands during your visit, Advise you to keep your hand elevated until bedtime, Advise you to limit the movement of your treated finger(s), Ask you to do simple finger exercises daily after the procedure, Advise you how long to wait before resuming normal activities with the treated hand, Return to the doctor about 30 days after the injection to have your finger(s) examined, Depending on your results, or if the cord(s) is still present, you may need additional injections and finger extension procedures (up to 3 times per cord), approximately 4 weeks apart, Signs of infection after your injection, such as fever, chills, increased redness, or swelling, Numbness or tingling in the treated finger(s), Trouble bending the injected finger(s) after the swelling goes down, Tears in the skin of your treated finger(s), swelling of the injection site or the hand, bruising or bleeding at the injection site, pain or tenderness of the injection site or the hand, swelling of the lymph nodes (glands) in the elbow or armpit. Move each finger from side to side (like a windshield wiper) one at a time; repeat 10 times. It is not known if XIAFLEX ® is safe and effective in children under the age of 18. XIAFLEX® is indicated for the treatment of adult patients with Dupuytren's contracture with a palpable cord. In the controlled and uncontrolled portions of clinical trials in Dupuytren's contracture, flexor tendon ruptures occurred after XIAFLEX, In the controlled portions of the clinical trials in Dupuytren's contracture, a greater proportion of XIAFLEX. © 2021 Endo Pharmaceuticals Inc. All rights reserved. If the disease progresses slowly, causes no pain and has little impact on your ability to use your hands for everyday tasks, you might not need treatment. On top of these kind of bad reactions, it is also coming out that Xiaflex has the worse recurrence rate of all the medical treatments for Dupuytren’s contracture; this means the Dupuytren’s contracture comes back faster and sooner after the Xiaflex procedure than after traditional hand surgery. XIAFLEX® can cause serious side effects, including: Before receiving XIAFLEX®, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX® injection, or have a bleeding problem or any other medical conditions. Dupuytren's Contracture Treatment Xiaflex. Xiaflex is also used to treat a related condition called Peyronie's disease in adult men. Evansville Indiana Orthopedic Surgeon Doctors physician directory - Dupuytren's contracture treatment options include Xiaflex injection, needle aponeurotomy, ultrasound, and cortisone injection. Please see the full Prescribing Information, including Medication Guide. Endo Pharmaceuticals Inc. is committed to respecting the privacy of its website visitors. For more information about how Endo Pharmaceuticals protects personal information about you, please read our Privacy Policy at www.endo.com/privacy-legal. XIAFLEX ® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. Using XIAFLEX® with certain other medicines can cause serious side effects. Currently, there are treatments for hand deformities caused by Dupuytren disease (“Dupuytren contracture”), but no treatment for the underlying process of Dupuytren disease. The Xiaflex procedure helps many Dupuytren’s contracture patients. Patients had finger extensions performed by a physician; were fitted with a splint; and were instructed to use a splint at bedtime for up to 4 months and perform daily finger exercises. XIAFLEX® can cause serious side effects such as tendon rupture or ligament damage. *, *In 2 clinical studies, patients were asked to rate their satisfaction with treatment on Day 90 as “very satisfied,” “quite satisfied,” “neither satisfied nor dissatisfied,” “quite dissatisfied,” or “very dissatisfied.” For data analysis, “satisfied” includes patients who chose “very satisfied” or “quite satisfied.”. Management of Dupuytren’s disease—clear advice for an elusive condition. Since 2002 our position has always been to recommend surgical intervention in those cases that have not responded to an aggressively applied round of conservative Alternative Medicine therapy. In these 2 clinical studies, patients received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt on Days 0, 30, and 60. The following steps can help you better understand what to expect. This bending is called a contracture and is caused by the abnormal formation of a cord(s) containing collagen under your skin. BioSpecifics Technologies Corp., a biopharmaceutical company developing first in … Endo Pharmaceuticals is not responsible for the content of linked sites. 83% (206 out of 249) of patients were satisfied with XIAFLEX® compared with 30% (38 out of 125) of patients with placebo. Contractures that have come backDupuytren’s contracture may come back no matter what option you use. Xiaflex is an injectable formulation of purified collagenase derived from the bacterium, Clostridium histolyticum. In: Biologics, Collagenase, Dupuytren's, Dupuytren's Contracture, Dupuytren's Disease, Xiaflex Feb 17, 2010 Auxilium has moved closer to product availability of Xiaflex collagenase injection for the treatment of Dupuytren’s contracture by announcing the wholesale drug price: $3250.00 for a single treatment … It is not known if XIAFLEX® is safe and effective in children under the age of 18. Bayat A, McGrouther DA. If you still have the cord, the doctor may try to extend the treated finger(s) and “break” the cord. The doctor may use local anesthetic during this procedure. Do not bend or straighten the treated finger(s) yourself. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger. The information contained in this section of the site is intended for US healthcare professionals only. In the controlled and uncontrolled portions of clinical trials in Dupuytren's contracture, flexor tendon ruptures occurred after XIAFLEX ® injection. Please see the full Prescribing Information, including Medication Guide. The most common side effects with XIAFLEX® in these studies were swelling of the injected hand and bruising or bleeding at the injection site. If your condition returns after treatment, nonsurgical XIAFLEX® may be used again. Tell your healthcare provider if you have any side effect that bothers you or does not go away. Images used with permission from physician and patient. They all believed Xiaflex is as good non-surgical treatment for Dupuytren’s contracture. Repeat 10 times. Malvern, PA 19355, XD-05939/September 2020 www.xiaflex.com 1-800-462-ENDO (3636). © 2019 Endo Pharmaceuticals Inc. All rights reserved. About 24 hours after each injection, patients had a finger extension procedure and were fitted with a splint to wear at bedtime for up to 4 months. Malvern, PA 19355 Use the unaffected hand to gently straighten the affected finger 10 times, holding for 5 to 10 seconds. Xiaflex® TREATMENT Today there is an FDA approved treatment for Dupuytren’ contracture with a medication called Xiaflex that is proving to be highly effective. XIAFLEX® should be injected by a healthcare provider who is experienced in injection procedures of the hand and in treating people with Dupuytren’s contracture. Please see the full Prescribing Information, including Medication Guide. Feldman G, Rozen N, Rubin G. Dupuytren's contracture: current treatment methods. Treatment for adults with Dupuytren’s contracture with a palpable cord, Important Safety Information for XIAFLEX®. Many Canadian patients have had the chance to benefit from this treatment. XIAFLEX ® is indicated for the treatment of adult patients with Dupuytren's contracture with a palpable cord. If you would like to email a link to this page of the website, provide your name and email address, as well as the recipients' email address(es), in the form fields below: Subject line: Information that may be of interest to you. This is to help straighten your finger(s). Repeat this exercise 4 times a day. The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include swelling of the injection site or the hand; bruising or bleeding at the injection site; pain or tenderness of the injection site or the hand; swelling of the lymph nodes (glands) in the elbow or armpit; itching; breaks in the skin; redness or warmth of the skin; pain in the armpit. Learn causes, risk factors, and symptoms. Twenty four hours later the patient returns to the office for the doctor to forcefully break the cords that were enzymatically weakened the day before, by taking the fingers into extension The cord was injected with XIAFLEX® and a finger extension procedure was performed 48 hours later. Repeat the exercise 4 times a day. This is to help straighten your finger(s). While certainly not exhaustive, this chart gives the highlights of the pros and cons of each treatment method. Multiple contractures in 1 handUp to 2 cords in 1 hand may be treated during 1 office visit. The cord was injected with XIAFLEX® and a finger extension procedure was performed 48 hours later, PIP=proximal interphalangeal Individual results may vary, Treatment of two contractures on the same hand, This patient had a cord that could be felt causing contractures of the MP and PIP joints of the left pinky finger. Irvine California Orthopedic Surgeon Doctors physician directory - Dupuytren's contracture treatment options include Xiaflex injection, needle aponeurotomy, ultrasound, and cortisone injection. XIAFLEX ® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. The most common side effects with XIAFLEX® for the treatment of Dupuytren’s contracture include: XIAFLEX® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. Nerve Injury. All of them say they wished they asked more questions about the doctor who did the Xiaflex procedure. XIAFLEX ® is a prescription medicine used to treat adults with Dupuytren’s contracture when a “cord” can be felt. Bend only the top 2 joints of all fingers, keeping your knuckles straight. 8% of those users who reviewed Xiaflex reported a positive effect, while 92% reported a negative effect. Privacy/Legal  XD-05702/February 2019  www.xiaflex.com 1-800-462-ENDO (3636). Dupuytren’s contracture is a disease that causes your finger(s) to bend inward. In these 2 studies, 60% of patients had a straight or nearly straight finger 30 days after the last injection on Days 30, 60, or 90 after up to 3 XIAFLEX® injections and finger extension procedures compared with 6% of patients who received placebo. Over the course of Dupuytren's disease, fibrous tissue in the palm thickens and tightens. Patients also performed finger exercises every day. Treatment for Dupuytren's contracture depends on the severity of your condition. In studies, patients received up to 3 injections of XIAFLEX® or placebo into a cord that could be felt at approximately 4-week intervals. This condition causes an abnormal thickening of the tissue in the palm of the hand. It starts breaking down the cord as soon as you receive the first injection. Actual patient. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX®. For treatment of Dupuytren’s contracture, the patient needs to be experiencing a cord-like fibrous growth in order for Xiaflex to be effective in treating the condition. Real Xiaflex patients tell what happened Note: Dupuytren’s contracture may return no matter what treatment is used. XIAFLEX is used for the treatment of Dupuytren’s contracture in adult patients with a palpable cord. After the extension procedure, the doctor will: Your first follow-up visit with the doctor will be approximately 1 to 3 days after the injection.